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Nutritional Supplement Store Covaxil Laboratories Trivestin for Significant Reduction of Joint Pain & Stiffness 56 ea Offering is as of March 2004. Click through for current info, pricing, and availability. Nutritional Supplements > Covaxil Nutritional Supplements > Item 1      Covaxil Laboratories Trivestin for Significant Reduction of Joint Pain & Stiffness 56 ea From the Manufacturer Clinical Trials Show Trivestin: Twice as Effective as Celebrex®** in Reducing Pain and Increasing Mobility.* The Proof Discussion:  With join pain adversely affecting more than 80 million Americans, science continues its search for the "perfect" join pain reliever.  Materials that have the ability to affect the IL-1 Beta inflammatory compound, the COX-2 inflammatory enzyme, and the 5-LO inflammatory pathway are prime targets.  For example, Celebrex®, the most popular prescription anti-inflammatory, has been shown to selectively inhibit the COX-2 enzyme (but not the 5-LO inflammatory pathway).  Glucosamine, a dietary supplement widely used in the treatment of join pain, is neither a selective COX-2 nor a selective 5-LO inhibitor (although it may have other benefits). Trivestin,™ a novel combination of plant extracts, singled out from more than 1,228 carefully screened candidate plants, was selected for its ability to block these established inflammatory enzymes and pathways.  Because rigorous laboratory trials confirmed Trivestin's proficiency in inhibiting gene expression of compounds that cause inflammation, pain, and join degradation (including IL-1 Beta, COX-2, and 5-LO), it was predicted that Trivestin would not only reduce pain, but also preserve the integrity of joint tissue.  To establish Trivestin's safety and efficacy (and mitigate the subjective nature of pain relief) a clinical trial was designed to compare Trivestin to both placebo and Celebrex, a recognized standard. Methods:  30-day, head-to-head, double-blind clinical date were evaluated to compare safety and efficacy of Trivestin to Celebrex.  four (4) groups:  Group 1 - Placebo (sugar pill);  Group 2 - Celebrex (200 mg per day);  Group 3 - Trivestin (250 mg per day); and Group 4 - Trivestin (500 mg per day).  Subjects were instructed to take the prescribed capsules in divided doses twice per day.  Improvements in join pain, mobility, flexibility, stiffness and ease of motion ("Quality of Life" parameters) were assessed at 30 days using the standard WOMAC(1) and SF-36 (Short-Form) evaluations. Results:  Trivestin was shown to be twice as effective as Celebrex (Group 3: p<0.06; Group 4:  p<0.05) [over and above placebo, of course] in reducing pain and stiffness, increasing mobility and flexibility, and improving overall quality of life. Conclusions: The ability of Trivestin to block multiple inflammatory enzymes and pathways (COX-2, IL-1 Beta and 5-LO) seems to account for Trivestin's superiority over Celebrex under the conditions of this double-blind clinical comparative trial. 1Western Ontario and McMaster Universities Osteoarthritis Index **Celebrex® is a registered trademark of G.D. Searle & Co Made in the U.S.A. *These statements have not been evaluated  by the Food and Drug Administration.  This product is not intended to diagnose, treat, cure, or prevent any disease. [U.S. Pat Pend./Under License] Covaxil Laboratories - "The name the world relies on for staying young." Safety Information If you are pregnant of lactating, consult a health-care professional before using this product. Ingredients Trevistat Forte A Proprietary Blend of Scutellaria Baicalensis (root) SE, Acacia Catechu (wood) SE, Medicago Sativa (leaf), Apium Graveolens (seeds), Arctium Lappa (root), Smilax mexicana (root), Capsicum annuum (fruit), Eupatorium Purpureum (root), Rice Flour Ingredients Trevistat Forte A Proprietary Blend of Scutellaria Baicalensis (root) SE, Acacia Catechu (wood) SE, Medicago Sativa (leaf), Apium Graveolens (seeds), Arctium Lappa (root), Smilax mexicana (root), Capsicum annuum (fruit), Eupatorium Purpureum (root), Rice Flour Directions Take one capsule with a full glass of water 2 or 3 times per day, depending upon severity of pain.  Do not exceed 3 capsules per day.  Trivestin™ may be taken with or without food.  If you are presently taking Celebrex®** or any prescription anti-inflammatory drug, check with your doctor before taking Trivestin or discontinuing your present medication. Store at controlled room temperature 15°-30° C/59°-86° F. Use only as directed. If your health care professional would like additional information on Trivestin:  please have him or her call 1-800-898-5153.